Changes

| base = carbamazepine

| add = lamotrigine

* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.

* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.

* This combination of drugs may have possible synergistic effects. However, the pharmacokinetic drug interactions will influence the plasma levels.

* Carbamazepine can reduce lamotrigine serum concentration considerably. Add lamotrigine according to the general dosing advice.

Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="torrentc"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by

carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>

}}