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* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
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* Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|9860152|Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43}}</ref><ref>{{drugscominteract|carbamazepine-with-zyprexa-497-0-1744-1113|carbamazepine|olanzapine}}</ref>
* Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref><ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref>
| cave = Interactions<ref>{{drugscominteract|carbamazepine-with-zyprexa-497-0-1744-1113|carbamazepine|olanzapine}}</ref>
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