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Created page with '{{Drugcombi | base = aripiprazole | add = topiramate | info = * Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite. * This combination of drugs may have p...'
{{Drugcombi
| base = aripiprazole
| add = topiramate
| info =
* Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">{{Drugscominteract|aripiprazole-with-topiramate-233-0-2216-0|aripiprazole|topiramate}}</ref>
* Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather.
}}
| base = aripiprazole
| add = topiramate
| info =
* Aripiprazole is metabolized by CYP2D6 and CYP3A4 to an active metabolite.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">{{Drugscominteract|aripiprazole-with-topiramate-233-0-2216-0|aripiprazole|topiramate}}</ref>
* Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather.
}}
