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| to = amitriptyline
| stop =
* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.* '''Day 7:''' stop administration of vortioxetine.
| start =
No wash-out period is needed.
* '''Day 18:''' simultaneously start administration of amitriptyline in a dosage of 25 mg/day. * '''Day 815:''' continue administration of amitriptyline in a dosage of 50 mg/day.
* Start low, go slow.
| info =
* {{theorSS}}
}}
