Changes

 * A wash'''Day 6 and after''': At approximately 50-out period 25% of 2 weeks is necessary, because the original vortioxetine dose start fluoxetine at 100% of CYP2D6-inhibitionthe target dose.* '''Day 22After 3 weeks:''' start administration If necessary, gradually increase dosage of fluoxetine in a normal dosage of 20 mg/day.{{Day22NoBloodlevelvortioxetine}} 

* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose fluoxetine = 20 mg* Fluoxetine is a strong inhibitor and norfluoxetine are inhibitors of CYP2D6(strong), which metabolizes vortioxetine. }}