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Created page with '{{Drugswitch | from = imipramine | to = paroxetine | stop = * '''Before day 0:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day. * '''Day 1:''' reduce dosage ...'
{{Drugswitch
| from = imipramine
| to = paroxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
* '''Day 8:''' stop administration of imipramine and continue administration of paroxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes imipramine. }}
| from = imipramine
| to = paroxetine
| stop =
* '''Before day 0:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
* '''Day 8:''' stop administration of imipramine and continue administration of paroxetine.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes imipramine. }}
