* '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day. {{stopSertraline}}
| start =
Caution is necessary.
* Sertraline dose-dependently slows the metabolism of imipramine via CYP2C9 and CYP2D6.
