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* '''Day 2: '''Start administration of imipramine in a dosage of 25-75 mg/day.
* If necessary, gradually increase the dose with about 25% of the target dose every 3 days under monitoring of bloodlevel. * Therapeutic Drug Monitoring of imipramine is useful, especially during the build up phase. Blood sampling is possible when reaching a steady state with the same dose after one week.
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