Difference between revisions of "Bupropion-venlafaxine"
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. | * By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. | ||
| − | * Bupropion slows the metabolism of venlafaxine by CYP2D6. | + | * Bupropion slows the metabolism of venlafaxine by CYP2D6.<ref> Stöllberger C, Huber JO, Finsterer J, [http://www.ncbi.nlm.nih.gov/pubmed/16096514?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Antipsychotic drugs and QT prolongation]. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.</ref> |
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Revision as of 13:53, 1 September 2009
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Switch medication from bupropion to venlafaxine.[1] [2]
Stop bupropion - Gradually reduce dosage of bupropion to a maximum of 150 mg/day.
- When a dosage of 150 mg/day is reached, stop administration.
Start venlafaxine- Day 1-7: a wash-out period of at least one week is necessary.
- Day 8: start venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
More information- By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
- Bupropion slows the metabolism of venlafaxine by CYP2D6.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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